They Said Months

Review >> They Said Months. I Chose Years! A Mesothelioma Survivor's Story

They Said Months. I Chose Years! A Mesothelioma Survivor's Story Review

They Said Months. I Chose Years! A Mesothelioma Survivor's Story Feature

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They Said Months. I Chose Years! A Mesothelioma Survivor's Story Overview

In October 2001, James O'Connor was diagnosed with mesothelioma, the asbestos caused cancer. His prognosis was less than a year to live. Surgery was not possible because of the position of the tumor and chemotherapy would decrease his quality of life and not significantly improve his length of life. His oncologist suggested that he take his wife on a cruise and start hospice care upon his return. James rejected the idea. Instead he was determined to survive this cancer. Working with other professional clinicians, he formulated a regimen of over 100 supplements a day, changed his diet, practiced mind-body medicine, and relied on his own discipline to see him through the difficult times ahead. More than six years later, James is alive and active. He enjoys his life and continues his holistic regimen every day.

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They Said Months. I Chose Years! A Mesothelioma Survivor's Story

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Mesothelioma Review

Mesothelioma Feature

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Mesothelioma Overview

Mesothelioma used to be a rare disease, but because of the widespread use of asbestos it has now been described as an epidemic around the world. The disease has proven exceptionally resistant to common forms of treatment (chemotherapy, radiotherapy and surgery). Mesothelioma has a very aggressive natural history with a median survival of around 9 months.

There has been an explosion in knowledge about mesothelioma in the past few years, partly stimulated by the formation of the International Mesothelioma Interest Group network. This book represents a state-of-the-art review of the disease, from laboratory through to the bedside, from diagnostic procedures through to treatment and from imaging and early detection through to medico-legal aspects. It will be of interest to any clinician or scientist with any involvement in asbestos-related diseases, as well as members of the legal profession and anyone with an interest in respiratory diseases.

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Brand: McGraw-Hill Medical

First Aid for the USMLE Step 1 2013 (First Aid USMLE)

 First Aid for the USMLE Step 1 2013 (First Aid USMLE) Review

First Aid for the USMLE Step 1 2013 (First Aid USMLE) Feature

• Used Book in Good Condition

First Aid for the USMLE Step 1 2013 (First Aid USMLE)

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First Aid for the USMLE Step 1 2013 (First Aid USMLE) Overview

THE WORLD'S BESTSELLING MEDICAL REVIEW BOOK--WITH MORE THAN 1,200 FREQUENTLY TESTED FACTS AND MNEMONICS

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Pleural Mesothelioma Medscape

Pleural Mesothelioma Medscape

Malignant Pleural Mesothelioma Treatment Protocols

Treatment Protocols

Treatment protocols for malignant pleural mesothelioma are provided below, including general approaches and treatment by surgical intervention, chemotherapy, radiotherapy, and trimodality therapy.
General treatment approach

Pleural Mesothelioma Medscape

Stage I resectable:

    Patients with operable disease may receive extrapleural pneumonectomy (EPP); if positive margins, add radiation therapy

Stage I unresectable:

    Observation for disease progression or
    Chemotherapy
    Radiation for positive margins

Pleural Mesothelioma Medscape

Stages II-III resectable:

    Induction chemotherapy (cisplatin and pemetrexed) or
    Surgery (pleurectomy/decortication or extrapleural pneumonectomy)
    Radiation
Pleural Mesothelioma Medscape
Stages II-III unresectable:

    Chemotherapy is recommended
    Radiation for palliation and positive margins

Stage IV:

    Chemotherapy
    Radiation post chemotherapy for palliation
    Surgery is not recommended for patients with stage IV disease

Surgical resection
Pleural Mesothelioma Medscape
The 2 surgical procedures commonly used in malignant mesothelioma are pleurectomy with decortication and EPP. For patients with early stage disease with favorable histology and good-risk patients, pleurectomy/decortication (P/D) is a good option. Patients with advanced disease and mixed histology and/or high risk should undergo P/D.
    Pleurectomy with decortication is a more limited procedure and requires less cardiorespiratory reserve; it involves dissection of the parietal pleura, incision of the parietal pleura, and decortication of the visceral pleura, followed by reconstruction; this procedure has a morbidity of 25% and a mortality of 2%
    Extrapleural pneumonectomy is a more extensive procedure than pleurectomy with decortication and has a higher mortality, although in recent years, the mortality has been lowered to 3.8%; this procedure involves dissection of the parietal pleura and division of the pulmonary vessels, as well as en bloc resection of the lung, pleura, pericardium, and diaphragm, followed by reconstruction
    EPP provides the best local control, because it removes the entire pleural sac along with the lung parenchyma
    With surgery alone, the recurrence rate is very high, and most patients die after a few months; at least half of the patients who have local control with surgery have distant metastasis upon autopsy
    In patients with the epithelioid type, if the patient is fit to tolerate a thoracotomy, the best option is still a thoracotomy and macroscopic clearance of the tumor as part of multimodality therapy

Chemotherapy

    Chemotherapy alone is recommended for patients with stage I-IV disease who are not candidates for surgery and for patients with sarcomatoid histology
    The mainstay of treatment is combination chemotherapy with pemetrexed and cisplatin
    Other combination therapies that have also been used are carboplatin and pemetrexed, which is beneficial in patients with poor performance status or who have comorbidities
    Combination cisplatin and gemcitabine may be used if patients cannot take pemetrexed ++

Pleural Mesothelioma Medscape

http://emedicine.medscape.com/article/1999348-overview +

Pleural Mesothelioma Medscape